A1 Journal article (refereed), original research

Modeling host-seeking behavior of African malaria vector mosquitoes in the presence of long-lasting insecticidal nets


Open Access publication

Publication Details
Authors: Shcherbacheva Anna, Haario Heikki, Killeen Gerry
Publisher: Elsevier
Publication year: 2018
Language: English
Journal acronym: Math. Biosci
Volume number: 295
Start page: 36
End page: 47
Number of pages: 12
ISSN: 0025-5564
eISSN: 1879-3134
JUFO-Level of this publication: 1
Open Access: Open Access publication

Abstract

The efficiency of spatial repellents and long-lasting insecticide-treated nets (LLINs) is a key research topic in malaria control. Insecticidal nets reduce the mosquito-human contact rate and simultaneously decrease mosquito populations. However, LLINs demonstrate dissimilar efficiency against different species of malaria mosquitoes. Various factors have been proposed as an explanation, including differences in insecticide-induced mortality, flight characteristics, or persistence of attack. Here we present a discrete agent-based approach that enables the efficiency of LLINs, baited traps and Insecticide Residual Sprays (IRS) to be examined. The model is calibrated with hut-level experimental data to compare the efficiency of protection against two mosquito species: Anopheles gambiae and Anopheles arabiensis. We show that while such data does not allow an unambiguous identification of the details of how LLINs alter the vector behavior, the model calibrations quantify the overall impact of LLINs for the two different mosquito species. The simulations are generalized to community-scale scenarios that systematically demonstrate the lower efficiency of the LLINs in control of An. arabiensis compared to An. gambiae.


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